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pentobarbital will lessen the extent or result of estradiol vaginal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.Keep an eye on Closely (one)pentobarbital will lower the level or impact of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Lack of, or diminished response